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KMID : 1123920100240040610
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Korean Journal of Oriental Physiology and Pathology
2010 Volume.24 No. 4 p.610 ~ p.615
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Effects of Medicinal Herbal Drink on Alcohol Metabolic Enzyme in Drunken Rats
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Hwang Su-Jung
Choi Hye-Min
Park Hyun-Jin
Lee Jin-Sang
Huh Dam
Kim Mi-Ryeo
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Abstract
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Alcohol is the most widely psychoactive drug and has known in almost all civilization since ancient time. Recently increase consuming alcoholic beverages, alcohol is on of the major public health problems in the world. Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) play important roles in the metabolism of alcohols and aldehydes. The drink consists of medicinal herbs, Puerariae Radix, Phyllostachyos Folium, Citri Pericarpium, Polygonati Rhizoma, Rehmanniae Rhizoma (Vinegar), which have been widely used in oriental medicine. This study was designed to investigate effects of medicinal herbal drink (MHD) on alcohol metabolism in drunken SD rats subjects. In experiment, rats were treated to ethanol (EtOH, 3 g/kg, PO) at 60 min. after saline (CON) or MHD (1 ml/kg, PO) administration. The blood alcohol concentration (BAC), blood acetaldehyde concentration (BALC) activities of ADH, ALDH, AST and ALT were significantly decreased in MHD group than in control group as a time-dependent manner. And drinking water volume in MHD group with duplicate treatment, were significantly decreased than in CON group. These results suggested that MHD intake could give an influence upon the reduction in BAC and BALC may alleviate acute ethanol-induced hepatotoxicity by altering alcohol metabolic enzyme activities.
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KEYWORD
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medicinal herbal drink, blood alcohol concentration, blood aldehyde concentration, alcohol dehydrogenase, aldehyde dehydrogenase
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